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Cinnamtannin A2

CAS No. 86631-38-1

Cinnamtannin A2 ( —— )

产品货号. M32135 CAS No. 86631-38-1

Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥5194 有现货
50MG 获取报价 有现货
100MG 获取报价 有现货

生物学信息

  • 产品名称
    Cinnamtannin A2
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone.
  • 产品描述
    Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone. Additionally, Cinnamtannin A2 exhibits antioxidant, anti-diabetic, and nephroprotective effects.
  • 体外实验
    Cinnamtannin A2 (0.125-2.0 μg/mL) inhibits LDL oxidation induced by copper ions or MeO-AMVN.
  • 体内实验
    Cinnamtannin A2 (10 mg/kg; i.p. for 30 days) ameliorates the level of KIM1 and NAGL in 5/6 nephractomized rats by regulating Nrf2- Keap1 pathway.Cinnamtannin A2 (10 μg/kg; p.o.) increases the secretion of insulin and glucagon-like peptide-1 (GLP-1) in plasma of mice. Cinnamtannin A2 (10 μg/kg; p.o.) significantly promotes phosphorylation of both IRB and IRS-1 in mice. Animal Model:Male Sprague-Dawley rats (250-300 g) were induced chronic renal failure (CRF) by removing the kidneys Dosage:10 mg/kg Administration:I.p. for 30 days Result:Ameliorated the altered level of creatinine, blood urea nitrogen, Neutrophil gelatinase-associated lipocalin, Kidney Injury Molecule-1 and cytokines in the serum and microalbuminurea.Reduced the oxidative stress level.Attenuated the altered expression of proteins involved in Nrf2-Keap1 pathway in the kidney tissue.Reduced the tubular injury score in the kidney tissue.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    86631-38-1
  • 分子量
    1155.1
  • 分子式
    C60H50O24
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    ——
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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